Strengthening Hearts by Addressing DisruptEd Sleep (SHADES) Mechanistic Trial
This mechanistic randomized controlled trial (R01 HL165115) seeks to determine if our modernized collaborative care intervention for insomnia improves biological factors (systemic inflammation, autonomic dysfunction, metabolic dysregulation, and proinflammatory gene expression) thought to explain how insomnia promotes cardiovascular disease and if these improvements are due to positive changes in sleep mechanisms.
​
200 patients with insomnia and elevated CVD risk are being recruited from the primary care clinics of Eskenazi Health, a safety net healthcare system in Indianapolis.
​
This is a 5-year study funded by the National Heart, Lung, and Blood Institute
​
HIV, Depression, and Insulin Resistance
This project (R01 DK141366) will fill a critical knowledge gap by determining the effects of depression treatment on insulin resistance, monocyte activation, and the metabolome in people with HIV treated with antiretroviral therapy.
The results from this randomized controlled trial will identify new treatment targets and lay the rationale for a future, large-scale trial of internet cognitive-behavioral therapy for depression to reduce incident diabetes in HIV.​
​
This is a 4-year study funded by the National Institute of Diabetes and Digestive and Kidney Diseases​
ADEPT-ICU
Full Title: Attenuating Depression with Internet Cognitive Behavioral Therapy (CBT) to Slow Cognitive Decline in Older Intensive Care Unit (ICU) Survivors
This randomized controlled trial will test the efficacy of an internet CBT intervention to reduce the burden of subjective cognitive decline (SCD) in older ICU survivors with moderate to severe depressive symptoms after ICU hospitalization.
​
300 patients who were recently discharged from an ICU stay with a depression diagnosis are being recruited in Indianapolis.
This is a 5-year study funded by the National Institute on Aging​
​
